Fig. 4

Effects of the coadministration of iridoids glycosids extract from the stem barks Feretia apodanthera (90 mg/kg) with flumazenil (1, 2, 3, 4, 5 and 6 mg/kg; Panel a) and FG7142 (4, 6, 8, 10, 12 and 14 mg/kg; Panel b), an inverse diazepam receptor agonist of the GABA_A receptor complex, on the convulsions induced in mice by acute 70 mg/kg pentylenetetrazole. N = 8 animals per dose. Data were analysis by Fisher Exact Test (two-tailed), ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001, significantly different compared to the vehicle; IGEFA, iridoids glycosids extract of Feretia apodanthera