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Table 2 Biological processes of nine IgA Nephropathy associated proteins, which were not covered by Gubentongluo decoction

From: A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy

GO ID

Term

P value

P value FDR

Gene

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

4.29E-08

5.31E-04

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0072413

signal transduction involved in mitotic cell cycle checkpoint

4.56E-08

5.64E-04

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0051436

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

4.56E-08

5.64E-04

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0031571

mitotic G1 DNA damage checkpoint

6.83E-08

8.46E-04

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0044783

G1 DNA damage checkpoint

7.21E-08

8.93E-04

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0071158

positive regulation of cell cycle arrest

1.04E-07

1.28E-03

PSMD1

    

PSMB1

    

PSMD2

    

PSMB5

GO:0016032

viral process

3.71E-07

4.59E-03

SYK

    

IL16

GO:0002376

immune system process

7.59E-06

9.39E-02

ADD2

    

SYK

    

MS4A1

GO:0043306

positive regulation of mast cell degranulation

1.45E-05

1.79E-01

SYK

    

MS4A1

GO:0051171

regulation of nitrogen compound metabolic process

4.45E-03

1.00E + 00

PDLIM1