Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study

Table 1 Changes of the body weight (g) and liver weight (g) in different experimental groups. Data represented as mean ± SD of six observations

	Initial body weight	Final body weight	% body weight change	Liver weight	Relative liver weight
Control	22.17 ± 0.70	24.23 ± 0.99*	9.26 ± 1.18 ▲	4.37 ± 0.21	18.04 ± 0.13
CCl₄	21.10 ± 0.34	17.49 ± 0.27***	17.07 ± 2.56 ▼	5.32 ± 0.18**	32.53 ± 3.03
Silymarin	21.64 ± 0.19	23.43 ± 0.25***	8.29 ± 1.39 ▲	4.30 ± 0.09^NS	18.37 ± 0.22
NOSE low	21.71 ± 0.49	22.36 ± 0.67^NS	3.96 ± 3.90 ▲	4.59 ± 0.16^NS	20.56 ± 1.36
NOSE high	22.25 ± 0.38	22.67 ± 0.18^NS	1.89 ± 2.38 ▲	4.55 ± 0.29^NS	20.05 ± 1.18
NORE low	22.14 ± 0.38	22.59 ± 0.21^NS	2.25 ± 2.02 ▲	4.41 ± 0.16^NS	19.50 ± 0.58
NORE high	22.20 ± 0.57	22.33 ± 0.46^NS	1.48 ± 0.26 ▲	4.24 ± 0.10^NS	19.00 ± 0.52

^NS p > 0.05, *p < 0.05, **p < 0.01 and ***p < 0.001. Final body weight was compared with initial body weight of corresponding group and liver weight of treated groups were compared with liver weight of control group. ▲ represents increase and ▼ represents decrease

ISSN: 2662-7671