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Table 4 Synergistic effect of gigantol combined with SA on high glucose-induced HLECs analyzed by Jin’s formula (q value listed in the table)

From: Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract

gigantol (μg/mL)

syringic acid (μg/mL)

0.125

0.625

1.25

2.5

0.1

1.21a*

1.17a

1.14

1.10

0.5

1.18a

1.22a*

1.18a

1.15a

1

1.13

1.14

1.26a*

1.17a

2

1.09

1.06

1.12

1.20a*

  1. According to Jin’s formula, q < 0.85 indicates antagonism, 0.85 ≤ q < 1.15 indicates additive effects, and q ≥ 1.15 indicates synergism (a). Synergism indicates that the effect of a mixture exceeds that expected from the individual components and additive effects (non-interaction) mean that the combined effect is equal to the expectation. The largest grades synergism efficiency when combination ratio of gigantol and SA was 1:1.25, * P < 0.05 vs the other combination ratio groups