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Table 1 IC50 values for P. curatellifolia, C. zeyheri and ethacrynic acid determined from direct interactions with GST in vitro. The IC50 values were determined by reading the concentration at 50 % inhibition from the dose response graphs

From: In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae)

Organ

Extract

IC50 (μg/ml)

ETA IC50 (μg/ml)

 

Parinari curatellifolia

  

Liver

Aqueous

24

6

Liver

Ethanol

12

10

Kidney

Aqueous

52

7.4

Kidney

Ethanol

52

3.7

 

Combretum zeyheri

  

Liver

Aqueous

68

5.4

Liver

Ethanol

1.3

10

Kidney

Aqueous

80

10

Kidney

Ethanol

1.4

3.1

  1. The IC50 values were obtained from Figs. 4–7. Each of the value was obtained from thesigmoidal dose–response curves as the concentration of the inhibitor was increased and are the mean of 4 values