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Fig. 8 | BMC Complementary and Alternative Medicine

Fig. 8

From: Paeoniflorin inhibits excitatory amino acid agonist-and high-dose morphine-induced nociceptive behavior in mice via modulation of N-methyl-D-aspartate receptors

Fig. 8

Effects of PF and antisense ODN of NMDA receptor subunit, NR2B on the NMDA receptor in mouse cortex by immunohistochemical assay. Antisense ODN subunit of NMDA receptor, NR2B (15 nM, i.c.v.) was administered once daily for 1–7 days. PF (100, 200, 500 nmol, i.c.v.) was administered 15 min before mice were sacrificed. The arrow was showing the NR2B positive cells. a: Normal control; b-d): treated with NR2B Day 1–7; e-f: PF 100–500 nmol combined treatment with NR2B in 7 days; h-j: treated with PF 500 nmol Day 1 ~ 7. Scare bar: 30 μm. (400×)

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