Fig. 6

Effect of PF and antisense ODN of NMDA receptor subunits on high dose morphine-induced clonic seizure-like excitation in mice. Antisense ODN subunits: NR1, NR2A, NR2B, NR2C (15nM, i.c.v.) were administered 24 h before morphine (250 nmol, i.t.) administration. PF (100, 200, 500 nmol, i.c.v.) was administered 15 min before morphine administration. a: onset, b: total numbers of morphine-induced clonic seizure-like excitation during the first 60 min after morphine administration was recorded. Data were shown as mean ± S.E. (n = 12). ^* p < 0.05, ^*** p < 0.001 compared with the morphine group. ^# p < 0.05, ^## P < 0.01, ^### P < 0.001 compared with itself antisense group