From: Acupuncture for insomnia after stroke: a systematic review and meta-analysis
Author (year) Country | Sample Size | Participants | Intervention Group Regimen | Control group regimen | Main outcomes | Results | |||
---|---|---|---|---|---|---|---|---|---|
Average age (years) | Sex (male/female) | Severity of insomnia | Time since stroke | ||||||
Ye 2013 [22] | 85 | (a) 62.8 ± 7.2 (b) 67.3 ± 8.3 | (a) 23/20 (b) 20/22 | (a) n.r. (b) n.r. | (a) 15.9 ± 3.5 days (b) 14.17 ± 2.9 days | (a) AT (n = 43) (GV-20, EX-HN3, EX-HN1, HT-7, EX/ 5 times a week for 4 weeks, 30 min) | (b) Drugs (n = 42) (Alprazolam 0.4 mg once a day for 4 weeks) | (1) PSQI (2) Efficacy standards of Chinese medicine | (1) Significant differences in PSQI scores (P < 0.05) (2) Significant differences in Effective rates (P < 0.01) |
Li 2012 [23] | 300 | (a) 49.2 (b) 51.3 | (a) 79/71 (b) 77/73 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AT + Drugs (n = 150) (BL-62, KI-6, HT-7/ once a day for 10 days, 30 min) | (b) Drugs (n = 150) (Estazolam 0.5 mg once a day for 10 days) | (1) Efficacy standards of Chinese medicine | (1) Significant differences in Effective rates (P < 0.05) |
Huang 2012 [24] | 84 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AT (n = 42) (GV-20, EX-HN1, Auricular Shenmen, EX-HN3, EX, KI-6, BL-62/ 6 times a week for 2 weeks, 30 min) | (b) Drugs (n = 42) (Estazolam 2 mg 4–7 times a day for 2 weeks) | (1) Efficacy standards of Chinese medicine | (1) Significant differences in Effective rates (P < 0.05) |
Wu 2012 [25] | 80 | (a) 67.6 ± 10.4 (b) 66.2 ± 9.6 | (a) 20/20 (b) 18/22 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AA (n = 40) (Auricular Shenmen, heart, kidney, subcortex, internal ear/ 4–5 times a day for 10 days) | (b) Drugs (n = 40) (Estazolam 2 mg once a day for 10 days) | (1) Efficacy standards of Chinese medicine | (1) Significant differences in Effective rates (P < 0.01) |
Huang 2011 [26] | 60 | (a) 66 (b) 67 | (a) 11/19 (b) 13/17 | (a) AIS > 6 (b) AIS > 6 | (a) n.r. (b) n.r. | (a) AT + Drugs (n = 30) (GV-20, EX-HN1, SP-6, BL-23, HT-7, EX/ once a day for 14 days, 30 min) | (b) Drugs (n = 30) (Bailemianjiaonang 0.27 g × 4 capsules twice a day for 20 days) | (1) PSQI | (1) Significant differences in PSQI scores (P < 0.01) |
Sun 2011 [27] | 60 | (a) 40 ± 15 (b) 40 ± 15 | (a) 14/16 (b) 15/15 | (a) PSQI 13.31 ± 2.4 (b) PSQI 12.09 ± 3.1 | (a) 4.0 ± 2.6 years (b) 3.9 ± 2.8 years | (a) AT + AA (n = 30) (AT: GV-20, HT-7, SP-6, GB-20, EX-HN5, EX-HN1, EX/ once a day for 20 days, 30 min); AA: HT-7, sympathetic/ twice a day for 20 days, 15 ~ 20 min) | (b) Drugs (n = 30) (Estazolam 2 mg once a day for 20 days) | (1) PSQI (2) Efficacy standards of Chinese medicine | (1) Significant differences in PSQI scores (P < 0.05) (2) Significant differences in Effective rates (P < 0.05) |
Ye 2010 [28] | 60 | (a) 61.5 ± 3.7 (b) 62.4 ± 4.9 | (a) 16/14 (b) 17/13 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AT (n = 30) (GV-24, GV-20, GV-16, GV-11, EX-HN1/ 6 times a week for 4 weeks, 30 min) | (b) Drugs (n = 30) (Diazepam 5.0 mg once a day for 4 weeks) | (1) Efficacy standards of Chinese medicine | (1) Significant differences in Effective rates (P < 0.01) |
Lee 2009 [20] | 52 | (a) 66.7 ± 11.0 (b) 66.0 ± 9.6 | (a) 12/15 (b) 12/13 | (a) ISI 18.4 ± 2.7, AIS 15.8 ± 2.4 (b) ISI 18.1 ± 2.6, AIS 14.9 ± 2.2 | (a) n.r. (b) n.r. | (a) IA (n = 27) (He7, EH6/ once a day for 3 days) | (b) Sham AT (n = 25) | (1) ISI (2) AIS | (1)Significant differences in ISI scores (P < 0.01) (2)Significant differences in AIS scores (P < 0.01) |
Lu 2008 [29] | 50 | (a) 61.48 ± 3.72 (b) 62.40 ± 4.88 | (a) 14/11 (b) 15/10 | (a) PSQI 16.64 ± 2.3 (b) PSQI 17.28 ± 2 | (a) 0.3 ~ 1 years (b) 0.3 ~ 1 years | (a) AT (n = 25) (GV-24, GV-20, GV-16, GV-11, BL-23, KI-3, HT-7, PC-6/ 6 days a week for 4 weeks, 30 min) | (b) Drugs (n = 25) (Diazepam 5.0 mg once a day for 4 weeks) | (1) PSQI | (1) Significant differences in PSQI scores (P < 0.05) |
Li 2007 [8] | 64 | (a) 69.8 ± 7.1 (b) 67.3 ± 8.3 | (a) 18/14 (b) 17/15 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AT + AA (n = 32) (AT: HT-7, SP-6, GV-24, EX-HN1, PC-6, LR-3, KI-3; AA: Auricular Shenmen/ 6 days a week for 4 weeks, 20–30 min) | (b) Drugs (n = 32) (Diazepam 2.5 mg or estazolam 1 mg once a day for 4 weeks) | (1) PSQI (2) Efficacy standards of Chinese medicine | (1) Significant differences in PSQI scores (P < 0.05) (2) Significant differences in Effective rates (P < 0.05) |
Liu 2006 [30] | 62 | (a) 69.9 ± 6.9 (b) 67.5 ± 8.2 | (a) 15/17 (b) 15/15 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) AT (n = 32) (HT-7, SP-6, GV-24, EX-HN1, PC-6, LR-3, KI-3, ST-36/ 5 days a week for 4 weeks, 30 min | (b) Drugs (n = 30) (Diazepam 2.5 mg or estazolam 1 mg once a day for 4 weeks) | (1) PSQI | (1) Significant differences in PSQI scores (P < 0.05) |
Kim 2004 [21] | 30 | (a) 65.1 ± 9.0 (b) 68.3 ± 10.4 | (a) 8/7 (b) 9/6 | (a) ISI 21.9 ± 2.0, AIS 17.1 ± 1.6 (b) ISI 22.3 ± 2.1, AIS 17.7 ± 2.5 | (a) n.r. (b) n.r. | (a) IA (n = 15) (He7, EH6/ once a day for 3 days) | (b) Sham AT (n = 15) | (1) ISI (2) AIS | (1) Significant differences in ISI scores (P < 0.01) (2) Significant differences in AIS scores (P < 0.01) |
Wang 2004 [31] | 64 | (a) 42.5 ~ 70.5 (b) 41 ~ 70 | (a) 22/12 (b) 17/13 | (a) n.r. (b) n.r. | (a) n.r. (b) n.r. | (a) EA + AA (n = 34) (EA: HT-7, PC-6, CV-12, ST-36, KI-3; AA: Auricular Shenmen/ 5 times a week for 4 weeks, 20–30 min, 40 Hz) | (b) Drugs (n = 30) (Diazepam 2.5 mg or clozapine 25 mg once a day for 4 weeks) | (1) PSQI (2) Efficacy standards of Chinese medicine | (1) Significant differences in PSQI scores (P < 0.01) (2) Significant differences in Effective rates (P < 0.01) |