Table 1 Odds ratio (95 % CI) by direct comparison (left lower part) and network meta- analysis (right upper part) based on ACR20

TwHF

15.56 (1.63–148.5)

12.09 (1.31–111.5)

11.76 (1.21–113.9)

0.89 (0.00–2.18e+28)

14.77 (1.59–137.2)

17.04 (1.76–165.3)

33.33 (4.17–100.0)

1.49 (0.73–3.08)

MTX

0.78 (0.43–1.41)

0.76 (0.35–1.61)

0.06 (0.00–1.35e+27)

0.95 (0.51–1.76)

1.10 (0.51–2.34)

2.38 (1.45–4.00)

–

0.94 (0.79–1.10)

LEF

0.97 (0.51–1.86)

0.07 (0.00–1.74e+27)

1.22 (0.76–1.97)

1.41 (0.74–2.70)

3.13 (2.27–4.17)

3.81(1.79–8.09)

0.89 (0.57–1.39)

1.25 (0.97–1.61)

SSZ

0.08 (0.00–1.79e+27)

1.26 (0.64–2.46)

1.45 (0.65–3.24)

3.23 (1.82–5.56)

–

–

0.47 (0.15–1.46)

–

CsA

16.52 (0.00–3.88e+29)

19.06 (0.00–4.48e+29)

50.00 (0.00–100.0)

–

–

–

–

–

FK506

1.15 (0.59–2.26)

2.56 (1.75–3.70)

–

–

–

–

–

–

MINO

2.22 (1.25–3.85)

36.77 (1.91–708.0)

2.41 (1.46–3.98)

3.03 (2.21–4.14)

3.18 (1.80–5.62)

–

2.38 (1.69–3.76)

2.19 (1.25–3.88)

Placebo