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Table 5 Inhibitory effect of FXC on inflammatory mediators in exudate of air pouch

From: Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies

    Estimated values/(Percent inhibition)
  Dose/route TNF-α (pg/ml) IL-6 (pg/ml) NO (μM/ml) PGE2 (pmole/ml)
Saline 2 ml i.p. 5.50 ± 1.04d 27.66 ± 5.00c 0.443 ± 0.058d 1301.8 ± 90.87b
Carrageenan 10 ml/kg p.o. 964.50 ± 95.525a 6291.3 ± 562.77a 0.784 ± 0.105a 1525.7 ± 75.76a
Diclofenac sodium 10 mg/kg p.o. 418.50 ± 57.83c 4544.8 ± 235.87b 0.362 ± 0.043c 1339.7 ± 25.17b
   56.44 ± 6.01 34.03 ± 3.42 56.11 ± 4.99 7.69 ± 1.73
FXC 100 mg/kg p.o. 592.33 ± 45.31b 5146.2 ± 257.58b 0.605 ± 0.060b 1404.7 ± 21.37ab
   38.35 ± 4.71 25.30 ± 3.73 26.71 ± 7.33 3.21 ± 1.47
FXC 200 mg/kg p.o. 505.67 ± 36.037bc 4398.2 ± 159.46b 0.408 ± 0.049bc 1309.8 ± 30.46b
   47.37 ± 3.75 36.16 ± 2.31 50.52 ± 5.96 9.74 ± 2.09
  1. FXC F. xanthoxyloides chloroform fraction, tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), nitric oxide (NO), prostaglandin E2 (PGE2). Count of cells is presented as mean ± SD (n = 6). One way analysis of variance for inflammatory mediators was followed by multiple comparisons by Tukeys’ HSD test. Superscript alphabets indicate significance among treatments (P <0.001) on not sharing common letter