Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies

Table 5 Inhibitory effect of FXC on inflammatory mediators in exudate of air pouch

			Estimated values/(Percent inhibition)
	Dose/route	TNF-α (pg/ml)	IL-6 (pg/ml)	NO (μM/ml)	PGE₂ (pmole/ml)
Saline	2 ml i.p.	5.50 ± 1.04^d	27.66 ± 5.00^c	0.443 ± 0.058^d	1301.8 ± 90.87^b
Carrageenan	10 ml/kg p.o.	964.50 ± 95.525^a	6291.3 ± 562.77^a	0.784 ± 0.105^a	1525.7 ± 75.76^a
Diclofenac sodium	10 mg/kg p.o.	418.50 ± 57.83^c	4544.8 ± 235.87^b	0.362 ± 0.043^c	1339.7 ± 25.17^b
		56.44 ± 6.01	34.03 ± 3.42	56.11 ± 4.99	7.69 ± 1.73
FXC	100 mg/kg p.o.	592.33 ± 45.31^b	5146.2 ± 257.58^b	0.605 ± 0.060^b	1404.7 ± 21.37^ab
		38.35 ± 4.71	25.30 ± 3.73	26.71 ± 7.33	3.21 ± 1.47
FXC	200 mg/kg p.o.	505.67 ± 36.037^bc	4398.2 ± 159.46^b	0.408 ± 0.049^bc	1309.8 ± 30.46^b
		47.37 ± 3.75	36.16 ± 2.31	50.52 ± 5.96	9.74 ± 2.09

FXC F. xanthoxyloides chloroform fraction, tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), nitric oxide (NO), prostaglandin E₂ (PGE₂). Count of cells is presented as mean ± SD (n = 6). One way analysis of variance for inflammatory mediators was followed by multiple comparisons by Tukeys’ HSD test. Superscript alphabets indicate significance among treatments (P <0.001) on not sharing common letter

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