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Table 1 Effect of FXM and its fractions in acetic acid induced writhing test in rat

From: Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies

Groups Drug (dose), route No. of writhing (Mean ± SD) % Inhibition
Saline 2 ml, i.p. 71.00 ± 2.52a 0
FXM 100 mg/kg, p.o. 30.50 ± 1.87g 57.04 ± 3.63
FXM 200 mg/kg, p.o. 22.00 ± 3.41h 69.01 ± 4.98
FXH 100 mg/kg, p.o. 63.50 ± 1.87b 10.56 ± 2.63
FXH 200 mg/kg, p.o. 51.00 ± 2.19de 28.16 ± 3.08
FXC 100 mg/kg, p.o. 39.16 ± 3.48f 44.83 ± 4.91
FXC 200 mg/kg, p.o. 16.16 ± 3.62ij 77.23 ± 5.64
FXE 100 mg/kg, p.o. 59.00 ± 1.41bc 16.90 ± 2.02
FXE 200 mg/kg, p.o. 48.00 ± 2.44e 32.39 ± 3.14
FXB 100 mg/kg, p.o. 55.66 ± 1.63cd 21.59 ± 2.30
FXB 200 mg/kg, p.o. 52.16 ± 1.16de 26.52 ± 1.64
FXA 100 mg/kg, p.o. 62.00 ± 1.78b 12.67 ± 2.51
FXA 200 mg/kg, p.o. 54.33 ± 1.75cd 23.47 ± 2.46
Diclofenac sodium 10 mg/kg, i.p. 14.16 ± 2.60j 80.04 ± 5.25
Aspirin 10 mg/kg, i.p. 19.16 ± 2.46hi 73.00 ± 4.87
  1. FXM F. xanthoxyloides methanol extract, FXH F. xanthoxyloides n-hexanefraction, FXC F. xanthoxyloides chloroform fraction, FXE F. xanthoxyloides ethyl acetate fraction, FXB F. xanthoxyloides n-butanol fraction, FXA F. xanthoxyloides residual aqueous fraction. Data values shown represent mean ± SD (n = 6). One-way ANOVA followed by Tukey’s HSD multiple comparison tests. Different alphabets in each column indicate difference at P <0.05