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Table 1 Effect of FXM and its fractions in acetic acid induced writhing test in rat

From: Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies

Groups

Drug (dose), route

No. of writhing (Mean ± SD)

% Inhibition

Saline

2 ml, i.p.

71.00 ± 2.52a

0

FXM

100 mg/kg, p.o.

30.50 ± 1.87g

57.04 ± 3.63

FXM

200 mg/kg, p.o.

22.00 ± 3.41h

69.01 ± 4.98

FXH

100 mg/kg, p.o.

63.50 ± 1.87b

10.56 ± 2.63

FXH

200 mg/kg, p.o.

51.00 ± 2.19de

28.16 ± 3.08

FXC

100 mg/kg, p.o.

39.16 ± 3.48f

44.83 ± 4.91

FXC

200 mg/kg, p.o.

16.16 ± 3.62ij

77.23 ± 5.64

FXE

100 mg/kg, p.o.

59.00 ± 1.41bc

16.90 ± 2.02

FXE

200 mg/kg, p.o.

48.00 ± 2.44e

32.39 ± 3.14

FXB

100 mg/kg, p.o.

55.66 ± 1.63cd

21.59 ± 2.30

FXB

200 mg/kg, p.o.

52.16 ± 1.16de

26.52 ± 1.64

FXA

100 mg/kg, p.o.

62.00 ± 1.78b

12.67 ± 2.51

FXA

200 mg/kg, p.o.

54.33 ± 1.75cd

23.47 ± 2.46

Diclofenac sodium

10 mg/kg, i.p.

14.16 ± 2.60j

80.04 ± 5.25

Aspirin

10 mg/kg, i.p.

19.16 ± 2.46hi

73.00 ± 4.87

  1. FXM F. xanthoxyloides methanol extract, FXH F. xanthoxyloides n-hexanefraction, FXC F. xanthoxyloides chloroform fraction, FXE F. xanthoxyloides ethyl acetate fraction, FXB F. xanthoxyloides n-butanol fraction, FXA F. xanthoxyloides residual aqueous fraction. Data values shown represent mean ± SD (n = 6). One-way ANOVA followed by Tukey’s HSD multiple comparison tests. Different alphabets in each column indicate difference at P <0.05