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Table 2 Characteristics and clinical findings of 10 MP cases

From: Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis

No. Age Sex Chief complaint/MP symptom Kampo formulas containing GF/Clinical findings GF intake cumulative dosage Administration period Pre-existing disease
1. 76 M Chief complaint Hypertension Orengedokuto 15,792 g 14.1 years DM, HT, LDL-c
MP symptom none Clinical findings (location) Colonoscopy: Bronze coloration (C to T) Redness and Erosion (C to A) Histology: Moderate fibrillization CT scan: Linear calcification (C to T) Wall thickening (C to A)
2. 76 M Chief complaint Hypertension Orengedokuto, Orengedokuto, Ryutansyakanto 14,683 g 15.9 years HT, LDL-c
MP symptom none Clinical findings (location) Colonoscopy: Bronze coloration (C to T) Histology: Severe fibrillization CT scan: Linear calcification (C to T) Wall thickening (C to A)
3. 70 M Chief complaint Hypertension Orengedokuto, Kamisyoyosan, Ryutansyakanto, Seihaito 8,119 g 11.9 years DM, HT, TG
MP symptom Ileus (Colectomy) Clinical findings (location) Histology: Fibrillization of the colonic mucosa and the mesenteric vein in excision sample CT scan: Linear calcification (C to T) Wall thickening (C to A)
4. 49 F Chief complaint Skin itching Unseiin, Kamisyoyosan, Keigairengyoto, Orengedokuto 7,972 g 12.2 years LDL-c
MP symptom none Clinical findings (location) Colonoscopy: Mild blue coloration (C to A) Decreased transparency of blood vessels (C to A) Histology: Mild fibrillization CT scan: Slight calcification, CT value increase, Mild vasodilation (the ileocecal vein)
5. 75 M Chief complaint Cutaneous pruritus Unseiin 6,579 g 6.8 years HT
MP symptom Constipation Abdominal pain Clinical findings (location) Colonoscopy: Dark blue coloration (C to T) Redness and Erosion (C to A) Histology: Severe fibrillization CT scan: Linear calcification (C to T) Wall thickening (C to T)
6. 58 F Chief complaint Dermatitis and Obesity Bofutsusyosan, Unseiin, Keigairengyoto, Orengedokuto 6,499 g 13.5 years LDL-c
MP symptom none Clinical findings (location) Colonoscopy: Edematous membrane and Bronze coloration (C to A) Histology: Concentric fibrillization surrounding capillary vessel
7. 68 M Chief complaint Cutaneous pruritus Unseiin 6,372 g 12.2 years DM, HT, LDL-c, TG
MP symptom none Clinical findings (location) Colonoscopy: Bronze coloration (C to T) Histology: Severe fibrillization CT scan: Linear calcification (the ileocolic vein)
8. 58 F Chief complaint Hot flush Kamisyoyosan, Kamikihito, Orengedokuto, Shin’iseihaito 5,588 g 4.0 years LDL-c, TG
MP symptom none Clinical findings (location) Colonoscopy: Bronze coloration (C to T) Histology: Mild - Moderate fibrillization CT scan: Slight calcification and CT value increase (C to A)
9. 64 F Chief complaint Flushed face, Feeling of cold Kamisyoyosan 5,408 g 11.4 years HT, LDL-c, TG
MP symptom none Clinical findings (location) Colonoscopy: Mild blue coloration (C to T) Histology: Mild - Moderate fibrillization CT scan: Linear calcification (C to A)
10. 67 F Chief complaint Hepatitis Orengedokuto 5,379 g 9.4 years Liver disease
MP symptom none Clinical findings (location) Colonoscopy: Mild blue coloration (C to T) Histology: Mild - Moderate fibrillization CT scan: Linear calcification (C to T) Wall thickening (C to A)
  1. CT computed tomography, GF gardenia fruit, MP mesenteric phlebosclerosis, DM diabetes mellitus, HT hypertension, LDL-c elevated low-density lipoprotein cholesterol, TG elevated triglyceride, C the caecum, A the ascending colon, T the transverse colon, Oblique type medicines, traditional decocted herbal medicines