Cytotoxic potential of selected medicinal plants in northeast Brazil

da Silva, Thiago B. C.; Costa, Cinara O. D’Sousa; Galvão, Alexandre F. C.; Bomfim, Larissa M.; Rodrigues, Ana Carolina B. da C.; Mota, Mauricio C. S.; Dantas, Alex A.; dos Santos, Tiago R.; Soares, Milena B. P.; Bezerra, Daniel P.

doi:10.1186/s12906-016-1166-1

BMC Complementary Medicine and Therapies

Table 3 IC₅₀ values of plant extracts/fractions and isolated compounds against tumor cell lines

From: Cytotoxic potential of selected medicinal plants in northeast Brazil

No.	Plant species	Parts of plant^a (Extractions^b)	Cells^c (IC₅₀ in μg/mL)^d
No.	Plant species	Parts of plant^a (Extractions^b)	B16-F10	HepG2	HL60	K562	PBMC
04	Byrsonima sericea DC.	L (m/e)	13.46	27.95	32.56	>50	33.81
04		L (m/e)	10.47–17.30	20.79–37.60	25.44–41.66	>50	26.45–43.23
05		L (ea/e)	17.44	41.53	28.21	>50	>50
05		L (ea/e)	13.95–21.81	35.31–48.85	21.18–37.57	>50	>50
07		L (h/e)	16.89	26.19	16.14	28.32	17.58
07		L (h/e)	14.63–19.49	23.14–29.64	13.85–18.82	16.96–47.29	10.01–30.86
11	Duranta repens Linn.	L (c/e)	29.00	33.78	22.41	21.12	>50
11	Duranta repens Linn.	L (c/e)	24.51–34.30	29.44–38.75	14.10–35.62	17.77–25.11	>50
56	Quercetin	-	12.12	12.15	8.81	14.93	14.39
56	Quercetin	-	9.92–14.81	9.82–15.05	7.28–10.65	13.90–16.04	11.18–18.52
19	Himatanthus bracteatus (A.DC.) Woodson	L (c/e)	22.43	24.75	23.06	29.85	12.53
19	Himatanthus bracteatus (A.DC.) Woodson	L (c/e)	20.80–24.18	21.70–28.22	20.62–25.79	26.87–33.15	8.28–18.96
20	Ipomoea purga (Wender.) Hayne	S (e)	7.39	8.52	9.39	8.53	6.99
20		S (e)	6.03–9.07	7.51–9.65	7.81–11.30	7.61–9.56	4.43–11.02
21		L (e)	16.30	29.63	32.64	28.95	30.71
21		L (e)	11.80–22.51	25.59–34.31	28.15–37.85	24.39–34.36	24.04–39.24
28	Ixora coccinea Linn.	F (c/e)	40.41	38.25	36.92	>50	>50
28	Ixora coccinea Linn.	F (c/e)	36.60–44.63	30.46–48.04	33.52–40.67	>50	>50
57	Mixture of α- and β-amyrin	-	23.21	24.09	>25	>25	Nd
57	Mixture of α- and β-amyrin	-	18.51–29.11	18.71–31.01	>25	>25	Nd
29	Mabea piriri Aubl.	S (e)	17.76	32.98	22.72	21.89	>50
29	Mabea piriri Aubl.	S (e)	13.42–23.51	27.61–39.40	13.26–38.91	15.52–30.87	>50
37	Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees)	L (e)	37.07	37.34	31.00	43.34	21.06
37	Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees)	L (e)	32.10–42.81	31.34–44.49	21.04–45.69	39.47–47.58	17.48–25.37
43	Psychotria capitata Ruiz & Pav.	L (ea/e)	15.58	18.32	18.91	31.38	12.73
43		L (ea/e)	11.29–21.51	14.91–22.50	13.93–25.67	22.78–43.22	7.43–21.81
44		L (c/e)	27.06	37.06	36.06	16.45	29.14
44		L (c/e)	19.26–38.02	31.54–43.53	28.65–45.40	13.16–20.56	22.46–37.82
	Doxorubicin^e		0.08	0.03	0.02	0.06	0.14
	Doxorubicin^e		0.06–0.11	0.02–0.03	0.02–0.02	0.04–0.09	0.02–1.08

Nd Not determined
^aParts of the plant: L leaves, S stem, and F Fruits
^bExtractions: h hexane, m methanol, e ethanol, m/e methanol/H₂O partition from the ethanolic extract, ea/e ethyl acetate partition from the ethanolic extract, h/e hexane partition from the ethanolic extract, c/e chloroform partition from the ethanolic extract, h:ea/e hexane:ethyl acetate (1:1) partition from the ethanolic extract
^cTumor cells: B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), HL-60 (human promyelocytic leukemia) and K562 (human chronic myelocytic leukemia). Non-tumor cells: PBMC (human peripheral blood mononuclear cells activated with concanavalin A – human lymphoblast)
^dData are presented as IC₅₀ values in μg/mL and their 95 % confidence interval obtained by nonlinear regression from three independent experiments performed in duplicate, measured using alamar blue assay after 72 h incubation. The negative control received the vehicle used to dilute the tested samples (0.5 % DMSO)
^eDoxorubicin was used as the positive control

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