Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial

Table 4 Changes in muscle damage markers, inflammatory and oxidative stress markers in response to downhill running exercise in the placebo and herb group

	Pre	90 min	24 h	48 h	72 h
Placebo
CRP, mg/dL
Control	0.07 ± 0.04	0.07 ± 0.04	0.07 ± 0.03	0.06 ± 0.02	0.05 ± 0.02
Exercise	0.08 ± 0.02	0.11 ± 0.05	0.15 ± 0.05*	0.11 ± 0.05	0.10 ± 0.03
CK, U/L
Control	94 ± 10	98 ± 8	89 ± 8	87 ± 9	90 ± 11
Exercise	93 ± 8	126 ± 13	396 ± 72^{, *}	257 ± 48^{, *}	192 ± 32*
Herb
CRP, mg/dL
Control	0.13 ± 0.05	0.14 ± 0.05	0.11 ± 0.04	0.11 ± 0.04	0.11 ± 0.03
Exercise	0.10 ± 0.03	0.09 ± 0.03	0.15 ± 0.03*	0.10 ± 0.02	0.10 ± 0.02
CK, U/L
Control	110 ± 12	108 ± 9	119 ± 17	109 ± 11	113 ± 16
Exercise	106 ± 9	195 ± 51*	291 ± 35^{, *}	204 ± 26^{, *}	151 ± 20
TBARs, μM
Placebo	7.1 ± 1.1	8.1 ± 1.5	7.9 ± 1.0	6.5 ± 1.0	-
Herb	7.0 ± 1.0	6.6 ± 0.8	8.1 ± 0.9	5.7 ± 0.6	-
IL-6, pg/ml
Placebo	0.44 ± 0.1	0.69 ± 0.1*	0.32 ± 0.1	0.46 ± 0.1	-
Herb	0.50 ± 0.2	0.45 ± 0.1	0.23 ± 0.1*	0.29 ± 0.1	-
TNF-α, pg/ml
Placebo	0.45 ± 0.14	0.28 ± 0.06	0.30 ± 0.06	0.30 ± 0.06	-
Herb	0.44 ± 0.06	0.34 ± 0.06	0.38 ± 0.08	0.34 ± 0.06	-

Values are means ± SEM. TBARs, IL-6, and TNF-α were measured only during the eccentric exercise session
CRP C-reactive protein, CK creatine kinase, TBARs thiobarbituric acid reactive substances, IL-6 interleukin-6, TNF-α tumor necrosis factor-α
*P<0.05 vs. Pre in the same condition. **P<0.05 vs. Control or Placebo at the same time point

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