Fig. 1From: Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathwayEffect of RCE on phosphorylation of AMPK and ACC in HepG2 cells.HepG2 cells were incubated in high-glucose medium (33 mM) for 16 h prior to the addition of the indicated concentrations of RCE or AICAR (2 mM). After pretreatment with RCE (μg/mL) for 6 h or AICAR for 2 h, p-AMPK and p-ACC expression levels were analyzed by western blotting (a). A quantitative analysis of the relative levels of p-AMPK (b) and p-ACC (c) was conducted. The results represent the mean ± SEM (n = 3), ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 vs. the sample without RCEBack to article page