Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Table 4 Antimalarial activities of aqueous, methanol and chloroform extracts of seeds of B. antidysenterica and mean survival time of P. berghie infected mice

Extraction solvents	B. antidysenterica	Extract antimalarial activity on D4 post-infection		Mean survival time (days)
	Dose (mg/kg)	% Parasitaemia ± SEM	% suppression	Mean survival time (days)
dH₂O	200	39.69 ± 1.10	24.05	9.25 ± 0.69^*
	400	32.19 ± 0.62	38.40	10 ± 00.54^*
	600	28.39 ± 1.68	45.68	12.50 ± 0.41^*
CH₃OH	200	34.36 ± 0.86	38.08	12.90 ± 1.04
	400	28.57 ± 1.31	43.33	14.80 ± 1.20^*
	600	27.99 ± 0.89	46.44	15.00 ± 1.40^*
CHCl₃	200	35.94 ± 0.86	31.23	12.00 ± 1.70^*
	400	29.67 ± 1.31	43.23	13.00 ± 0.80^*
	600	27.33 ± 0.89	47.70	15.50 ± 0.41^*
Controls	QC (25 mg)	0.00 ± 0.00	100.00	ND
Controls	T80	52.26 ± 1.50	0.00	7.00 ± 0.50

Key: Values are presented as M ± SEM; n = 5; T80 = negative control (3 % tween 80); CQ positive control (chloroquine), ND no death within the follow-up interval (30-days), dH ₂ O distilled water, CH ₃ OH methanol, CHCl ₃ chloroform, CQ chloroquine (positive control); ^* = values are significantly different (p < 0.05) from that of the negative control

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