Antidiabetic activity of the ethyl acetate fraction of Ficus lutea (Moraceae) leaf extract: comparison of an in vitro assay with an in vivo obese mouse model

Table 1 The total polyphenol content and EC₅₀ of α-amylase and α-glucosidase activity of fractions of F. lutea extract

Fractions	^aTotal polyphenol (mg GAE/g dry weight extract)	^aα-Amylase inhibition (EC₅₀) μg/ml	^aα-Glucosidase inhibition (EC₅₀) μg/ml
Hexane	14.86 ± 1.43^b	˃1000	˃1000
Chloroform	10.32 ± 0.82^b	˃1000	˃1000
Dichloromethane	11.83 ± 2.32^b	˃1000	854.51 ± 56.92^c
Ethyl acetate	100.51 ± 1.60^c	39.53 ± 7.10^c	126.78 ± 30.62^e
n-Butanol	79.58 ± 0.50^d	26.50 ± 1.22^d	195.17 ± 63.60^d
Water	13.34 ± 0.85^b	˃1000	558.40 ± 51.67^c
^fAcarbose	-	7.71 ± 0.42^b	6.28 ± 0.03^b

^aValues are means of triplicate determinations done three times (n = 9) ± standard error;
^b,c,d,eNo significant difference between extracts with same value, but significant difference p ˂ 0.05 between different values
^fPositive control for α-amylase and α-glucosidase

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