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Table 2 Effect of Acarbose and the protein extracts from MCC and MCM on peak blood glucose (PBG) and area under the curve (AUC) after starch (3 g/kg) and sucrose (4 g/kg) loading in diabetic and non- diabetic rats. Values are the mean ± SEM (n = 5), at P < 0.05 vs. control

From: In vitro and in vivo α-amylase and α-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.)

Group

Starch

Sucrose

PBG (mg/dL)

% Reduction of PBG

AUC (mg/dL)

% Reduction of AUC

PBG (mg/dL)

% Reduction of PBG

AUC (mg/dL)

% Reduction of AUC

Diabetic control

367.5 ± 0.87

 

702.7 ± 0.97

 

343 ± 0.92

 

646 ± 0.79

 

Diabetic + Acarbose

277.8 ± 0.76

24.43

520.2 ± 0.59

25.97

254.3 ± 0.69

25.86

470 ± 0.88

27.24

Diabetic + MCC

289.8 ± 0.91

21.15

524.8 ± 0.65

25.32

267 ± 0.75

22.16

474.5 ± 0.95

26.55

Diabetic + MCM

282.8 ± 0.82

23

522.8 ± 0.78

25.6

261 ± 0.87

23.91

472 ± 0.58

26.94

Control

172 ± 0.56

 

382 ± 0.63

 

184 ± 0.81

 

394 ± 0.64

 

Acarbose

151 ± 0.81

12.2

305.4 ± 0.67

20.05

146 ± 0.94

20.65

295.4 ± 0.56

25.03

MCC

161.2 ± 0.65

6.28

319.1 ± 0.82

16.47

153.8 ± 0.73

16.41

308.8 ± 0.52

21.62

MCM

155 ± 0.65

9.88

309.8 ± 0.56

18.9

150.2 ± 0.67

18.37

301.6 ± 0.82

23.45