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Table 4 Possible protective mechanisms of TCMCR

From: Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury

Possible drug protective mechanisms

Studies

Increase in cerebral microvascular patency and integrity

[11]

Improve cognitive deficits

[3, 4]

Ameliorated cerebral edema

[1, 58, 10, 1316, 19, 26]

Attenuated disruption of the blood–brain-barrier

[1, 7, 8, 10, 11, 14, 16, 24, 25]

Reduced the neuronal apoptosis

[9, 21]

Suppressed oxidative stress

[5, 18, 20]

Regulation of cerebral blood flow

[4, 8, 22, 23]

Increase activities of Na+-K+-ATPase、Ca2+-ATPase and regulation of Ca2+

[12]

promote the synthesizing and secreting of apolipoprotein E

[17]

Inhibited the inflammatory response

[5, 8, 19, 20, 26]