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Table 4 Possible protective mechanisms of TCMCR

From: Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury

Possible drug protective mechanisms Studies
Increase in cerebral microvascular patency and integrity [11]
Improve cognitive deficits [3, 4]
Ameliorated cerebral edema [1, 58, 10, 1316, 19, 26]
Attenuated disruption of the blood–brain-barrier [1, 7, 8, 10, 11, 14, 16, 24, 25]
Reduced the neuronal apoptosis [9, 21]
Suppressed oxidative stress [5, 18, 20]
Regulation of cerebral blood flow [4, 8, 22, 23]
Increase activities of Na+-K+-ATPase、Ca2+-ATPase and regulation of Ca2+ [12]
promote the synthesizing and secreting of apolipoprotein E [17]
Inhibited the inflammatory response [5, 8, 19, 20, 26]