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Table 4 Evaluation of the ulcerogenic activity of Diclofenac (Diclo) and OP5

From: Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities

Groups Doses (mg/kg) Mucus weight (mg) Total surface of stomach (mm2) ulcerated surface (mm2) % of ulcerated animals
Control   0.163 ± 0.013 1479.00 ± 72.79 0.00 ± 0.00 0
Diclo 5 0.073 ± 0.014* 1406.00 ± 78.92 221.10 ± 0.00*** 100
OP5 2,5 0.127 ± 0.018 1886.00 ± 127.00 0.00 ± 0.00 0
OP5 5 0.090 ± 0.009 1723.00 ± 46.90 0.00 ± 0.00 0
  1. Each value represents the mean ± SEM of eight animals.*p < 0.05, ***p < 0.001 significant difference compared to the control group. Diclo diclofenac