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Table 3 Effects of different treatments on the biochemical parameters of oxidative stress and hepatotoxicity

From: Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities

Parameters Tissue Control Diclofenac (5 mg/kg) OP5 (2.5 mg/kg) OP5 (5 mg/kg)
NO (μmol/g tissue) liver 0.49 ± 0.06 0.28 ± 0.06* 0.48 ± 0.04 0.36 ± 0.03
kidney 1.014 ± 0.11 0.66 ± 0.15 1.23 ± 0.15 0.85 ± 0.06
Glutathione (μmol/g tissue) liver 0.12 ± 0.01 0.11 ± 0.01 0.12 ± 0.01 0.10 ± 0.01
kidney 0.07 ± 0.01 0.04 ± 0.01 0.09 ± 0.01 0.07 ± 0.00
MDA (μmol/g tissue) liver 9.37 ± 0.74 9.80 ± 0.46 3.10 ± 0.37*** 9.42 ± 0.24
kidney 0.12 ± 0.01 0.09 ± 0.02 0.14 ± 0.01 0.12 ± 0.00
SOD (U/mg protein) liver 0.05 ± 0.01 0.12 ± 0.00* 0.08 ± 0.02 0.11 ± 0.01*
kidney 0.19 ± 0.08 0.12 ± 0.05 0.09 ± 0.02 0.10 ± 0.04
Catalase (U/mg protein) kidney 0.08 ± 0.01 0.08 ± 0.01 0.10 ± 0.02 0.08 ± 0.01
ALAT (U/mg protein) serum 0.39 ± 0.15 0.4 ± 0.01 0.60 ± 0.08 0.80 ± 0.21
ASAT (U/mg protein) serum 1.28 ± 0.10 1.58 ± 0.13 1.35 ± 0.07 1.313 ± 0.11
  1. Each value represents the average ± ESM of eight animals.* p < 0.05, *** p < 0.001 significant difference compared to the control group