Fig. 7
From: Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities
Time-dependant acute (panel a) effect of Pallidioside B (OP5) and Pallidioside C (OP6) and repeated treatment of OP5 (panel b) on mechanical pain induced by Randal sellito in rat paw injected with formalin (2 %, 100 μl). Animals were orally treated with different compounds and injected one hour later in the paw with formalin. Pain threshold was measured before treatment and after formalin injection. For chronic experiment, animals were daily treated and pain threshold was measured before drug administration. Each point represents the mean ± SEM, n = 8. *P < 0.05, **p < 0.01, ***p < 0.001 significant differences compared to the control. Diclo: diclofenac