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Table 3 Effects of rutin on intestinal cytokines induced by methotrexate in rats

From: Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects

Groups Treatment IL-2 (pg/ml) IL-4 (pg/ml) IL-10 (pg/ml)
Group-I Sham control (Normal saline, 3.0 ml/kg) 398.10 ± 5.32 162.18 ± 8.79 63.09 ± 5.51
Group-II Toxic control (MTX, 2.5 mg/kg) 671.93 ± 56.65a 213.79 ± 7.64a 88.57 ± 3.45a
Group-III Rutin (50 mg/kg) 174.15 ± 8.20***a 193.50 ± 1.47***a 104.05 ± 0.65**a
Group-IV Rutin + MTX(50 + 2.5 mg/kg) 233.52 ± 14.69***a 117.29 ± 0.023***a 63.21 ± 2.96
Group-V Rutin (100 mg/kg) 178.72 ± 3.28***a 198.26 ± 7.76***a 122.11 ± 1.88***a
Group-VI Rutin + MTX (100 + 2.5 mg/kg) 272.02 ± 15.00***a 179.24 ± 1.57*** 96.99 ± 1.50***a
  1. Each group contains six animals. Values are represented as mean ± SEM
  2. Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test
  3. *P < 0.05, **P < 0.01, and ***P < 0.001 were considered statistically significant
  4. Statistical significance compared to normal control (Group-I) using one-way ANOVA followed by Bonferroni test
  5. c P < 0.05, b P < 0.01 and a P < 0.001 were considered statistically significant