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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Herbal preparation (HemoHIM) enhanced functional maturation of bone marrow-derived dendritic cells mediated toll-like receptor 4

Fig. 7

HemoHIM bound TLR4 but not TLR2 and induced BMDC activation. a Histograms of CD40, CD80, CD86, and MHC II expression by HemoHIM treated (100 μg/ml) CD11c-gated DCs derived from wild-type, TLR2-/-, or TLR4-/- mice. DCs derived from wild-type, TLR2-/- and TLR4-/- mice were treated with HemoHIM for 24 h. The percentages of positive cells are shown in each panel. b IL-1β, IL-6, and TNF-α production by HemoHIM-, LPS-, or Pam3-treated DCs derived from wild-type, TLR2-/-, or TLR4-/- mice were determined by ELISA. The results are representative of three experiments. *, p < 0.05, **, p < 0.01, and ***, p < 0.001 vs. untreated BMDCs. +, p < 0.05, ++, p < 0.01, and +++, p < 0.001 vs. HemoHIM-treated BMDCs from wild-type and TLR2-/- mice

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