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Table 5 Effect of EAF on levels of PGE2 and NO in the stomach tissue of the ethanol-treated rats

From: Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Experimental groups

Dose (mg/kg)

Prostaglandin E2(pg/mg protin)

NO (μM/g tissue)

Normal (untreated)

-

188.39 ± 4.66**

43.06 ± 4.83**

Vehicle + ethanol

-

159.90 ± 6.49##

22.25 ± 1.65##

Ranitidine + ethanol

100

186.88 ± 3.39**

45.73 ± 4.22**

EAF + ethanol

100

178.12 ± 5.07

42.61 ± 2.25**

 

250

191.94 ± 5.24***

47.25 ± 4.46***

 

500

201.07 ± 4.20***

56.47 ± 4.61***

  1. Values are expressed as mean ±  SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the vehicle group. Student’s t-test was performed for comparing normal and vehicle group, significant at## p < 0.01