Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Table 3 Effect of EAF on gastric juice parameters in pylorus-ligated rat model

Treatment	Volume of gastric juice (ml)	pH	Free acidity (meq/l)	Total acidity (mEq/l)	Total protein (mg/ml)
Control (8 % tween 80)	7.75 ± 1.18	1.26 ± 0.08	103.30 ± 7.53	142.50 ± 9.69	5.45 ± 0.17
Ranitidine	2.25 ± 0.38***	2.73 ± 0.38**	52.67 ± 5.70***	80.67 ± 7.87***	3.78 ± 0.28***
EAF 100 mg/kg	3.38 ± 0.86**	1.97 ± 0.31	97.00 ± 8.42	128.70 ± 4.22	4.32 ± 0.31**
250 mg/kg	1.83 ± 0.23***	1.94 ± 0.20	62.83 ± 7.08***	99.00 ± 6.46***	4.61 ± 0.10*
500 mg/kg	4.02 ± 0.64**	1.69 ± 0.25	77.50 ± 3.43*	115.20 ± 4.80*	4.50 ± 0.13*

Values are expressed as mean ± SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the control group

ISSN: 2662-7671