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Table 1 Cytotoxicity of Polyphyllin VII (PP7) against human liver cancer cells (HepG2, Hep3B, Bel7402 and 7721). Cells were treated with increasing concentrations of PP7 for 24, 48 and 72 h and cell viability was determined by MTT assay as described in Methods section. Each IC50 value represents means ± SD of 3 to 5 independent experiments

From: Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

Cell line

 

IC50 (μM)

 
 

24 h

48 h

72 h

HepG2

1.32 ± 0.04

0.85 ± 0.03

0.78 ± 0.04

Hep3B

2.61 ± 0.08

1.84 ± 0.06

1.23 ± 0.05

Bel7402

2.86 ± 0.15

1.74 ± 0.06

1.12 ± 0.04

7721

2.30 ± 0.09

1.73 ± 0.05

1.28 ± 0.05