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Table 4 Effect of the drug treatments on the intestinal tissue pro-oxidant and antioxidant parameters on day nine of sacrifice in indomethacin induced CD in rats

From: Emu oil offers protection in Crohn’s disease model in rats

Group

CAT

SOD

GPX

GSH

MDA

Myeloperoxidase

(μM of H2O2 decomposed/min/mg protein)

(enzyme required to inhibit 50 % pyrogallol autoxidation/min/mg protein)

(μM of glutathione utilized/min/mg protein)

(mg/g of tissue)

(mM of MDA/g of tissue)

(U/mg of protein)

Control

8.53c ± 0.29

6.46b ± 0.55

5.70c ± 0.4

2.39a ± 0.29

56.68c ± 2.48

16.63a ± 1.85

Indomethacin

3.11a ± 0.31

1.67a ± 0.166

1.56a ± 0.08

30.62c ± 4.28

24.62a ± 1.72

46.65c ± 2.27

Sulfasalazine

6.11abc ± 0.94

3.47ab ± 0.19

3.25ab ± 0.52

13.68b ± 1.92

31.49ab ± 3.02

25.46ab ± 1.77

Aloe vera

4.35ab ± 0.52

3.20a ± 0.18

2.47a ± 0.19

15.82b ± 0.99

36.76ab ± 1.59

32.65b ± 2.64

Emu oil

6.26abc ± 0.74

3.75ab ± 0.16

4.48bc ± 0.69

8.93ab ± 0.63

44.75bc ± 2.45

30.85b ± 3.80

Aloe vera and emu oil combination

6.91bc ± 0.18

4.55ab ± 0.15

4.95bc ± 0.12

8.33ab ± 0.80

37.66bc ± 5.23

29.68b ± 2.07

  1. All the values were expressed as Mean ± S.E. (n = 6) and means bearing different superscripts in a column differ significantly