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Table 3 Effect of drug treatments on the intestinal tissue pro-oxidant and antioxidant parameters on day six of sacrifice in indomethacin induced CD in rats

From: Emu oil offers protection in Crohn’s disease model in rats

Group

CAT

SOD

GPX

GSH

MDA

Myeloperoxidase

(μM of H2O2 decomposed/min/mg protein)

(enzyme required to inhibit 50 % pyrogallol autoxidation/min/mg protein)

(μM of glutathione utilized/min/mg protein)

(mg/g of tissue)

(mM of MDA/g of tissue)

(U/mg of protein)

Control

8.73b ± 0.01

6.15b ± 0.55

5.17c ± 0.49

2.85a ± 0.25

54.58d ± 1.16

15.40a ± 0.84

Indomethacin

2.37a ± 0.07

1.73a ± 0.28

1.44a ± 0.35

27.01d ± 1.47

27.77a ± 1.18

63.29c ± 4.79

Sulfasalazine

6.12ab ± 1.37

3.31a ± 0.33

3.52bc ± 0.22

11.90c ± 0.59

31.83ab ± 2.29

39.06b ± 1.03

Aloe vera

4.26ab ± 0.5

2.74a ± 0.33

2.91ab ± 0.19

10.96c ± 0.58

34.75ab ± 1.25

39.89b ± 2.25

Emu oil

5.97ab ± 0.50

2.95a ± 0.44

3.67bc ± 0.42

8.36bc ± 0.91

41.71bc ± 2.13

35.36b ± 0.64

Aloe vera and emu oil combination

6.07ab ± 1.02

3.22a ± 0.26

3.97bc ± 0.68

5.92ab ± 1.40

46.58cd ± 3.06

33.66b ± 4.14

  1. All the values were expressed as Mean ± S.E. (n = 6) and means bearing different superscripts in a column differ significantly