Table 1 Schedule for the treatment and outcome measurements

3

Informed consent

●

Demographic characteristics

●

Vital signs

●

●

●

●

●

●

●

●

●

Blood test

●

●

Medical history

●

Inclusion/Exclusion criteria

●

Conformity assessment

●

Treatment expectancy questionnaire

●

Random allocation

●

Treatment

●

●

●

●

●

●

●

●

Prescription of rescue medicine

●

PI-NRS

●

●

●

●

●

●

●

●

NDI

●

●

CROM

●

●

HRV

●

●

Perceived stress scale

●

●

EQ-5D

●

●

PGIC

●

Pressure pain threshold

●

●

Consumption of rescue medicine

●

Days of restricted activity

●

●

Blinding test

●

●

Safety assessment

●

●

●

●

●

●

●

●