Fig. 3
From: Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis
Effects of boiogito and indomethacin on hyaluronic acid (HA) in a rat model of knee osteoarthritis (OA). The contents of HA in the articular cavity (a) were increased but HA concentrations in the synovial fluid (b) were decreased in rats with OA (Con, n = 12) compared with those in sham-operated rats (Sham, n = 8). Daily administration of boiogito (2 %, n = 12) did not change the HA content but recovered the decreased HA concentration in synovial fluid. These parameters were not influenced by indomethacin (Ind, n = 11). Results are expressed as mean ± SE. ##P < 0.01 vs. Sham, **P < 0.01 vs. non-treated control rats with OA (Con)