Types | DMEs | Inhibitors | IC50 a | Â |
---|---|---|---|---|
EEDS (μg/mL) | Inhibitors (μM) | |||
Ph I | CYP1A2 | α-naphthoflavone | 47.3 ± 7.0 | 0.22 ± 0.03 |
 | CYP2C8 | Montelukast | >100 | 0.31 ± 0.02 |
 | CYP2C9 | Sulfaphenazole | 25.8 ± 1.9 | 0.13 ± 0.01 |
 | CYP2C19 | Ticlopidine | 38.7 ± 2.5 | 0.39 ± 0.03 |
 | CYP2D6 | Quinidine | 137.5 ± 0.3 | 0.08 ± 0.00 |
 | CYP3A4 | Ketoconazole | 134.2 ± 3.5 | 0.25 ± 0.03 |
Ph II | UGT1A1 | Diclofenac | 335.1 ± 57.3 | 180.3 ± 29.6 |
 | UGT2B7 | Diclofenac | >500 | 179.4 ± 30.9 |
Drug transport | P-gp | Na3VO4 | >500 | 3.40 ± 0.32 |