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Table 3 IC50 of EEDS on human DMEs

From: Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro

Types

DMEs

Inhibitors

IC50 a

 

EEDS (μg/mL)

Inhibitors (μM)

Ph I

CYP1A2

α-naphthoflavone

47.3 ± 7.0

0.22 ± 0.03

 

CYP2C8

Montelukast

>100

0.31 ± 0.02

 

CYP2C9

Sulfaphenazole

25.8 ± 1.9

0.13 ± 0.01

 

CYP2C19

Ticlopidine

38.7 ± 2.5

0.39 ± 0.03

 

CYP2D6

Quinidine

137.5 ± 0.3

0.08 ± 0.00

 

CYP3A4

Ketoconazole

134.2 ± 3.5

0.25 ± 0.03

Ph II

UGT1A1

Diclofenac

335.1 ± 57.3

180.3 ± 29.6

 

UGT2B7

Diclofenac

>500

179.4 ± 30.9

Drug transport

P-gp

Na3VO4

>500

3.40 ± 0.32

  1. aValues are expressed as the means ± S.D. of at least duplicated experiments