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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro

Fig. 1

Left panel, primary Lineweaver-Burk plots for CYP1A2, CYP2C9, and CYP2C19. The modes of enzyme inhibition were determined by incubating an enzyme with a combination of different concentrations of EEDS and increasing the concentrations of specific substrates. Right panel, secondary plots for CYP1A2, CYP2C9, and CYP2C19. Ki value was calculated by the secondary plot representing the slope rate of the Lineweaver-Burk plot versus increasing the concentrations of EEDS. Minus Ki values (-Ki) from the plot intersect on the x-axis

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