Fig. 10

Western blot analysis for p53 and Cleaved-caspase3 expression. p53 expression was detected by western blot analysis. Our data showed a significant expression of p53 in samples collected seven days after CIR-induction. Conversely, levels of p53 were clearly reduced by administration of bioactive TBK-SE (a). GAPDH was used as internal control. **p < 0.05 vs CIR. By western blot analysis the activation of cleaved-caspase 3 was evaluated. CIR caused a significant increase in cleaved-caspase 3 expression. On the contrary, treatment with bioactive TBK-SE prevented the CIR-induced caspase 3 expression (b). GAPDH was used as internal control. **p < 0.05 vs CIR