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Table 3 Effect of S. crispus crude ethanol extract on gene expression of colon tissues of AOM-induced CRC in rats

From: Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo

Genes Slc26a3 Defa24 APC Bax Bcl2
Animal groups
Calibrator (Normal) 0 0 0 0 0
AOM −4.47 ± 0.43b 9.49 ± 0.48b −1.38 ± 0.31a −1.40 ± 0.21a 1.49 ± 0.21a
S. crispus 250 mg/kg 3.96 ± 0.54ab −1.90 ± 0.60ab 1.528 ± 0.34b 1.66 ± 0.29b 1.17 ± 0.24
S. crispus 500 mg/kg 5.37 ± 0.41ab −1.46 ± 0.70ab 1.52 ± 0.33b 1.71 ± 0.35b 1.26 ± 0.16
  1. The values were expressed as mean ± SEM, representing fold changes of target gene expression. Two-tailed unpaired student’s test was used. aSignificant difference at the 0.05 level between AOM-induced group and calibrator; bsignificant difference between treated groups and induced (AOM) group