Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo

Table 3 Effect of S. crispus crude ethanol extract on gene expression of colon tissues of AOM-induced CRC in rats

Genes	Slc26a3	Defa24	APC	Bax	Bcl2
Animal groups	Slc26a3	Defa24	APC	Bax	Bcl2
Calibrator (Normal)	0	0	0	0	0
AOM	−4.47 ± 0.43^b	9.49 ± 0.48^b	−1.38 ± 0.31^a	−1.40 ± 0.21^a	1.49 ± 0.21^a
S. crispus 250 mg/kg	3.96 ± 0.54^a^b	−1.90 ± 0.60^a^b	1.528 ± 0.34^b	1.66 ± 0.29^b	1.17 ± 0.24
S. crispus 500 mg/kg	5.37 ± 0.41^a^b	−1.46 ± 0.70^a^b	1.52 ± 0.33^b	1.71 ± 0.35^b	1.26 ± 0.16

The values were expressed as mean ± SEM, representing fold changes of target gene expression. Two-tailed unpaired student’s test was used. ^aSignificant difference at the 0.05 level between AOM-induced group and calibrator; ^bsignificant difference between treated groups and induced (AOM) group

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