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Table 3 Effects of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus on gastric lesions induced by ethanol in rats pretreated with L-NAME

From: Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus

Pretreatment

Treatment (p.o.)

Dose (mg/kg)

UI (mm)

Increase lesion (%)

Saline

Saline

10

17 ± 5,5

-

L-NAME (70 mg/Kg)

Saline

10

59 ± 15*

247

L-NAME (70 mg/Kg)

Sa-FRF

100

39 ± 5,4*

129

L-NAME (70 mg/Kg)

Sa-FDF

 

22 ± 1,9

29

Saline

Saline

10

16 ± 5,7

-

L-NAME (70 mg/Kg)

Saline

10

60 ± 14**

275

L-NAME (70 mg/Kg)

Sb-FRF

100

32 ± 6,3*

100

L-NAME (70 mg/Kg)

Sb-FDF

100

20 ± 3,5

25

  1. ANOVA followed by Dunnett’s test.*p < 0.05, **p < 0.01. Data are presented as mean ± S.D (n = 5-7)