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Table 3 Effects of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus on gastric lesions induced by ethanol in rats pretreated with L-NAME

From: Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus

Pretreatment Treatment (p.o.) Dose (mg/kg) UI (mm) Increase lesion (%)
Saline Saline 10 17 ± 5,5 -
L-NAME (70 mg/Kg) Saline 10 59 ± 15* 247
L-NAME (70 mg/Kg) Sa-FRF 100 39 ± 5,4* 129
L-NAME (70 mg/Kg) Sa-FDF   22 ± 1,9 29
Saline Saline 10 16 ± 5,7 -
L-NAME (70 mg/Kg) Saline 10 60 ± 14** 275
L-NAME (70 mg/Kg) Sb-FRF 100 32 ± 6,3* 100
L-NAME (70 mg/Kg) Sb-FDF 100 20 ± 3,5 25
  1. ANOVA followed by Dunnett’s test.*p < 0.05, **p < 0.01. Data are presented as mean ± S.D (n = 5-7)