Table 1 IC50 values of analogs against NCI-H322, A549 cancer lines
Entry | Lung (NCI-H322) | Lung (A549) |
|---|---|---|
IC50 (μM) | ||
Juglone | 19.32 ± 0.83 | 16.70 ± 0.88 |
15a | 8.90 ± 0.20 | 4.72 ± 0.20 |
15b | 15.60 ± 0.83 | 12.86 ± 0.48 |
15c | 10.96 ± 0.68 | 10.20 ± 0.43 |
16a | 7.94 ± 0.34 | 4.67 ± 0.18 |
16b | 17.22 ± 1.18 | 15.08 ± 0.92 |
16c | 13.30 ± 0.87 | 12.95 ± 0.81 |
17a | 29.08 ± 1.20 | 23.83 ± 1.54 |
17b | 26.52 ± 1.20 | 20.28 ± 1.15 |
17c | 32.88 ± 1.63 | 25.32 ± 1.77 |
18a | 24.34 ± 1.28 | 20.55 ± 0.82 |
18b | 21.82 ± 1.25 | 19.12 ± 0.89 |
18c | 24.55 ± 1.54 | 20.26 ± 0.72 |
19a | 18.98 ± 0.99 | 15.12 ± 0.47 |
20a | 18.28 ± 0.96 | 12.88 ± 0.42 |
BEZ-235 | 9.80 ± 0.25 | 6.28 ± 0.28 |