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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Icariin protects rats against 5/6 nephrectomy-induced chronic kidney failure by increasing the number of renal stem cells

Fig. 7

Proposed model for the actions of icariin in alleviating CKD. Icariin activates the expression of genes promoting the proliferation, survival, and differentiation of renal stem cells (e. g. HGF, BMP-7, Pax-2, and WT-1) and inhibits genes promoting inflammation and fibrosis (e. g. TGF-β1), which leads to the increase of renal stem/progenitor cells and the repair of kidney injuries

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