Fig. 4From: Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascadeEvaluation of NO production by HUVEC stimulated with histamine which pre-treated by AEBO. Three independent experiments were performed in triplicate. Data were expressed in mean ± SEM. *P < 0.05, significant different compared with the negative control by One-way ANOVA, Post Hoc, Tukey test. (B = basal level; N = Treated with histamine only; P = Drug control, 10 μM of L-NAME)Back to article page