Table 4 Quality assessment of the included studies

Research question specified and clear?

√

√

√

√

√

√

√

√

√

√

√

√

Outcome measures relevant for AD research

√

√

√

√

√

√

√

√

√

√

√

√

Are the characteristics of study population clear?

Species

√

√

√

√

√

√

√

√

√

√

√

√

Background/generation

√

√

√

√

√

√

√

√

√

√

√

√

Sex (and distribution)

√

√

√

√

√

N

√

N

√

√

√

N

Age

N

√

√

√

√

√

√

√

√

√

√

√

Presence and correct control group?

√

√

√

√

√

√

√

√

√

√

√

√

Where the groups similar at baseline (if not randomized think of weight and sex etc.)?

√

√

√

√

√

N

√

N

√

?

√

N

Is the experiment randomized?

√

√

√

√

√

N

√

N

√

√

√

√

Kind of supplement mentioned (ginsenoside)?

√

√

√

√

√

√

√

√

√

√

√

√

Age when supplementation started mentioned?

√

√

√

√

√

√

√

√

√

√

√

√

Duration of supplementation clear and specified?

√

√

√

√

√

√

√

√

√

√

√

√

Amount of ginsenoside mentioned

√

√

√

√

√

√

√

√

√

√

√

√

Administration route specified

√

√

√

√

√

√

√

√

√

√

√

√

Is the timing of the supplementation during the day specified and similar in both groups?

√

√

√

√

√

√

√

√

√

√

√

√

Methods used for outcome assessment the same in both groups?

√

√

√

√

√

√

√

√

√

√

√

√

Did report animals who died or were otherwise removed from the study

N

N

N

N

N

N

N

N

N

N

N

N

Blinded outcome assessment?

N

√

N

N

N

N

N

N

N

N

N

N

Was the outcome assessment randomized across the groups?

N

N

N

N

N

N

N

N

N

N

N

N

Total number of animals included in statistical analyses clear?

√

√

√

√

√

√

√

√

√

√

√

√

Age of sacrificing animals mentioned?

√

√

√

√

√

√

√

√

√

√

√

√

Quality score (items√)

17

19

18

18

18

15

18

15

18

17

18

18