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Table 7 Antifungal activity of leaf, stem and fruit extracts of D. innoxia tested against filamentous fungi

From: Extraction optimization of medicinally important metabolites from Datura innoxia Mill.: an in vitro biological and phytochemical investigation

Extracts aDiameter of growth inhibition zone (mm ± SD)
A. fumigatus MIC μg/ml Mucor sp. MIC μg/ml A. niger MIC μg/ml A. flavus MIC μg/ml
Leaf
 Nh 8 ± 3.24c 100 10 ± 2.85b 100 7 ± 2.21d 100 -- --
 C 8 ± 1.43c 100 -- -- 9 ± 1.32d 100 -- --
 A 7 ± 1.56d 100 8 ± 1.34c 100 22 ± 1.5b 25 -- --
 EthA 7 ± 2.45d 100 12 ± 3.45b 50 10 ± 1.78c -- -- --
 Eth -- -- 7 ± 1.67d 100 -- -- -- --
 EC -- -- -- -- -- -- -- --
 MC -- -- -- -- -- -- -- --
 EthE 7 ± 1.22d 100 10 ± 3.27b 100 -- -- -- --
 Meth -- -- 9 ± 1.65c 100 -- -- -- --
 E -- -- 7 ± 2.43d 100 10 ± 1.45c 100 -- --
 M -- -- 9 ± 2.56c 100 7 ± 1.67d 100 -- --
 D -- -- 8 ± 1.54c 100 --   -- --
Stem
 Nh -- -- 10 ± 1.67c 50 8 ± 2.34c 100 10 ± 1.8c 100
 C -- -- 14 ± 0.88b 50 8 ± 1.45c 100 9 ± 1.21c 100
 A -- -- 7 ± 1.21d 100 20 ± 2.23b 25 --  
 EthA -- -- 10 ± 2.67c 50 7 ± 1.22d 100 --  
 Eth -- -- 7 ± 2.34d 100 --   --  
 EC -- -- 7 ± 1.23d 100 13 ± 1.32c 100 --  
 MC 9 ± 1.87c 100 9 ± 1.56c 100 --   7 ± 2.21d 100
 EthE 8 ± 2.14d 100 --   7 ± 1.45d 100 --  
 MEth -- -- --   7 ± 0.77d 100 --  
 E -- -- 10 ± 2.13c 100 8 ± 1.82d 100 --  
 M 9 ± 2.32c 100 6 ± 1.43d 100 7 ± 1.23d 100 8 ± 1.21c 100
 D -- -- 10 ± 1.56c 100 --   --  
Fruit
 Nh -- -- 12 ± 1.21 100 24 ± 1.32b 12.5 -- --
 C 8 ± 1.23d 100 8 ± 2.45d 100 9 ± 1.22c 100 9 ± 1.32c 100
 A 8 ± 1.45d 100 7 ± 1.13d 100 8 ± 1.45d 100 -- --
 EthA -- -- 13 ± 2.21 50 10 ± 3.12b 100 10 ± 1.21b 100
 Eth -- -- -- -- 16 ± 1.67b 12.5 -- --
 EC -- -- 8 ± 1.56d 100 -- -- -- --
 MC -- -- 10 ± 1.56c 50 9 ± 1.82c 100 -- --
 EthE -- -- 11 ± 1.65c 100 8 ± 1.21d 100 -- --
 MEth 9 ± 1.76c 100 10 ± 1.67c 100 8 ± 2.13d 100 -- --
 E 10 ± 1.12c 100 12 ± 2.21 50 8 ± 1.23d 100 12 ± 1.28b 100
 M 7 ± 1.23d 100 12 ± 1.54 50 9 ± 1.51c 100 -- --
 D -- -- -- -- 10 ± 1.21b 100 -- --
  1. aZone of inhibition including the diameter of disc (5 mm). In each disc, the sample size was 100 μg per disc (5 μl) in disc diffusion assay. Values (mean ± SD) are average of three samples of each plant extract, analyzed individually in triplicate (n = 1 × 3). b-d Means difference is highly significant, slightly significant, and significant at p < 0.05. --: No activity in disc diffusion assay or not active (zone ≥ 10 mm) for MIC determination