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Table 6 Antibacterial activity of leaf, stem and fruit extracts of D. innoxia

From: Extraction optimization of medicinally important metabolites from Datura innoxia Mill.: an in vitro biological and phytochemical investigation

Extracts

aDiameter of growth inhibition zone (mm ± SD)

K. pneumoniae

MIC (μg/ml)

S. typhimurium

MIC (μg/ml)

M. luteus

MIC (μg/ml)

S. aureus

MIC (μg/ml)

Leaf

 Nh

8.5 ± 0.76d

--

10 ± 2.85b

33.33

7 ± 1.84d

--

9 ± 1.89c

--

 C

10 ± 0.96c

33.33

6.5 ± 1.32b

--

9 ± 1.45d

--

9 ± 2.31c

--

 A

10 ± 0.76c

33.33

7.5 ± 1.33d

--

14.5 ± 1.1b

3.70

10 ± 1.63b

100

 EthA

10 ± 0.98c

100

7 ± 1.54d

--

12 ± 1.17c

33.33

9 ± 1.78c

--

 Eth

12 ± 0.22c

100

8 ± 1.24c

--

18 ± 1.34b

3.70

8 ± 1.49d

--

 EC

10 ± 0.48c

100

7.5 ± 1.34d

--

12 ± 1.22b

33.33

8.5 ± 1.87d

--

 MC

7 ± 0.45d

--

6 ± 2.21d

--

16 ± 1.45b

3.70

6 ± 1.89d

--

 EthE

12 ± 0.18b

33.33

7.5 ± 1.76d

--

14 ± 1.45c

33.33

7 ± 2.21d

--

 Meth

9.5 ± 0.34c

--

7 ± 1.32d

--

10 ± 1.34c

100.00

8. 5 ± 1.38d

--

 E

8 ± 0.67d

--

17 ± 1.45d

11.11

13 ± 1.45c

11.11

9.5 ± 1.22b

--

 M

7 ± 0.34d

--

8 ± 1.24c

--

16 ± 1.67b

3.70

7 ± 1.23d

--

 D

7 ± 0.56d

--

7 ± 1.23d

--

14 ± 1.13c

11.11

6 ± 1.43d

--

Stem

 Nh

--

--

10 ± 1.67c

33.33

8 ± 2.34c

--

10 ± 1.83b

100

 C

--

--

14 ± 0.88b

11.11

8 ± 1.45c

--

9 ± 1.21c

--

 A

--

--

7 ± 1.21d

--

8 ± 2.2b

--

--

--

 EthA

--

--

10 ± 2.67c

100

7 ± 1.22d

--

--

--

 Eth

--

--

7 ± 2.34d

--

--

--

--

--

 EC

--

--

7 ± 1.23d

--

13 ± 1.3b

100

--

--

 MC

9 ± 1.87c

--

9 ± 1.56c

--

--

--

7 ± 2.21d

--

 EthE

8 ± 2.14c

--

--

 

7 ± 1.45d

--

--

--

 Meth

--

--

--

 

7 ± 0.77d

--

--

--

 E

--

--

10 ± 2.13c

100

20 ± 1.82c

3.70

--

--

 M

9 ± 2.32c

--

6 ± 1.43d

--

7 ± 1.23d

--

8 ± 1.21c

--

 D

--

--

10 ± 1.56c

100

0

--

--

--

Fruit

 Nh

--

--

12 ± 1.21b

100

24 ± 1.32b

3.70

--

--

 C

8 ± 1.23c

--

8 ± 2.45d

--

9 ± 1.22c

--

9 ± 1.32d

--

 A

8 ± 1.45c

--

7 ± 1.13d

--

8 ± 1.45d

--

--

--

 EthA

--

--

13 ± 2.21b

33.33

10 ± 3.12c

100

10 ± 1.21c

100

 EC

--

--

8 ± 1.56d

--

--

--

--

--

 MC

--

--

10 ± 1.56c

100

9 ± 1.82c

--

--

--

 EthE

--

--

11 ± 1.65c

100

8 ± 1.21d

--

--

--

 Meth

9 ± 1.76c

--

10 ± 1.67c

100

8 ± 2.13d

--

--

--

 E

10 ± 1.12b

100

12 ± 2.21b

100

8 ± 1.23d

--

12 ± 1.28b

33.33

 M

7 ± 1.23d

--

12 ± 1.54b

33.33

9 ± 1.51b

--

--

--

 D

--

--

--

--

10 ± 1.21c

100

--

--

 DMSO

--

--

--

--

--

--

--

--

 Cefixime

28 ± 0.07

3.33

26 ± 0.21

3.33

18 ± 0.44

1.11

16 ± 1.22

1.11

  1. aZone of inhibition including the diameter of disc (5 mm). In each disc, the sample size was 100 μg per disc (5 μl) in disc diffusion assay. Values (mean ± SD) are average of three samples of each plant extract, analyzed individually in triplicate (n = 1 × 3). b-d Means difference is highly significant, slightly significant, and significant at p < 0.05. --: No activity in disc diffusion assay or not active (zone ≥ 10 mm) for MIC determination