Table 3 Effects of the subchronic oral administration of OS-EL on hematological parameters in Sprague Dawley rats
Control water | OS-EL (mg/kg) 250 | 500 | 1000 | ||
|---|---|---|---|---|---|
Female rats | |||||
Haemoglobin | g/L | 141 ± 2.64 | 148.66 ± 3.14 | 147.6 ± 3.74 | 143.5 ± 2.84 |
RBC | 1012 | 7.68 ± 0.21 | 8.03 ± 0.09 | 7.82 ± 0.26 | 7.54 ± 0.13 |
PCV | L/L | 0.44 ± 0.01 | 0.48 ± 0.01 | 0.45 ± 0.01 | 0.46 ± 0.00 |
MCV | f/L | 58 ± 0.70 | 60 ± 1.94 | 58.8 ± 3.15 | 62 ± 0.96 |
MCH | Pg | 18.2 ± 0.2 | 18.66 ± 0.51 | 18.8 ± 0.66 | 19.25 ± 0.42 |
MCHC | g/L | 317 ± 3.88 | 308.66 ± 2.06 | 323.6 ± 6.91 | 307 ± 6.16 |
RDW | % | 13.01 ± 3.24 | 15.16 ± 0.88 | 16.5 ± 1.30 | 14.27 ± 0.25 |
White cell count | 109/L | 8.78 ± 1.14 | 6.36 ± 0.88 | 5.74 ± 0.69 | 7.17 ± 0.33 |
Neutrophils | 109/L | 1.82 ± 0.31 | 2.06 ± 0.18 | 2.02 ± 0.58 | 1.97 ± 0.36 |
Lymphocytes | 109/L | 6.66 ± 0.85 | 3.83 ± 0.60* | 3.5 ± 0.18 | 4.55 ± 0.18 |
Monocytes | 109/L | 0.14 ± 0.07 | 0.36 ± 0.06 | 0.2 ± 0.05* | 0.425 ± 0.04 |
Eosinophils | 109/L | 0.18 ± 0.02 | 0.06 ± 0.02 | 0.05 ± 0.02 | 0.15 ± 0.02 |
Platelets | 109/L | 543.4 ± 93.91 | 657.66 ± 56.86 | 520 ± 40.72 | 573.75 ± 84.71 |
Reticulocytes | 109/L | 225.5 ± 9.28 | 270.33 ± 54.17 | 283.4 ± 16.28 | 222.5 ± 10.26 |
Prothrombin time | Seconds | 15.32 ± 0.38 | 15.5 ± 0.00 | 15.6 ± 0.27 | 15.55 ± 0.36 |
I.N.R | 1.3 ± 0.03 | 1.28 ± 0.03 | 1.23 ± 0.02 | 1.3 ± 0.03 | |
A.P.T.T | Seconds | 42.07 ± 2.10 | 49.9 ± 1.52 | 41.9 ± 2.73 | 42.07 ± 2.10 |
Male rats | |||||
Haemoglobin | g/L | 149.6 ± 2.82 | 152.75 ± 2.69 | 158 ± 3.97 | 158 ± 2.12 |
RBC | 1012 | 8.80 ± 0.24 | 8.74 ± 0.10 | 8.94 ± 0.22 | 8.99 ± 0.07 |
PCV | L/L | 0.46 ± 0.00 | 0.47 ± 0.01 | 0.47 ± 0.01 | 0.46 ± 0.00 |
MCV | f/L | 52.8 ± 1.01 | 53.75 ± 0.92 | 52.66 ± 1.43 | 52 ± 0.44 |
MCH | Pg | 17 ± 0.31 | 17.5 ± 0.25 | 17.66 ± 0.25 | 17.6 ± 0.24 |
MCHC | g/L | 322.2 ± 2.57 | 325 ± 9.59 | 335.66 ± 5.59 | 337.6 ± 3.66 |
RDW | % | 16.7 ± 0.74 | 16.45 ± 0.51 | 16.33 ± 0.18 | 16.32 ± 0.45 |
White cell count | 109/L | 10.88 ± 1.29 | 9.77 ± 3.11 | 8 ± 1.42 | 7.34 ± 1.12 |
Neutrophils | 109/L | 4.88 ± 0.76 | 4.45 ± 2.16 | 4.03 ± 1.02 | 2.94 ± 0.42 |
Lymphocytes | 109/L | 5.28 ± 0.44 | 4.7 ± 0.99 | 3.53 ± 0.40 | 3.8 ± 0.66 |
Monocytes | 109/L | 0.44 ± 0.11 | 0.4 ± 0.14 | 0.2 ± 0.07 | 0.48 ± 0.07 |
Eosinophils | 109/L | 0.23 ± 0.02 | 0.2 ± 0.01 | 0.16 ± 0.05 | 0.17 ± 0.06 |
Platelets | 109/L | 559 ± 20.04 | 488.25 ± 41.98 | 484 ± 73.94 | 487.8 ± 54.36 |
Reticulocytes | 109/L | 267.8 ± 17.19 | 320.25 ± 15.57 | 252 ± 28.25 | 224.6 ± 11.33 |
Prothrombin time | Seconds | 16.67 ± 0.49 | 15.57 ± 0.31 | 16.65 ± 0.34 | 17.44 ± 0.21 |
I.N.R | 1.37 ± 0.06 | 1.25 ± 0.04 | 1.35 ± 0.03 | 1.46 ± 0.02 | |
A.P.T.T | Seconds | 43.46 ± 1.76 | 42.17 ± 3.90 | 46.85 ± 2.30 | 50.32 ± 3.42 |