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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway

Fig. 1

XNJ inhibits p53 transcriptional activity. a Serum-free condition induced the p53 transcriptional activity. PC12 cells were transfected with p53 promoter reporter construct and then stimulated with serum or serum-free condition for 6, 12, 24 and 36 h respectively. b p53 inhibitor, pifithrin α, inhibited p53 transcriptional activity. PC12 cells were transfected with p53 promoter reporter construct and then stimulated with serum or serum-free condition for 12 h in the absence or presence of pifithrin α. c XNJ inhibited p53 transcriptional activity. PC12 cells were transfected with p53 promoter reporter construct and then stimulated with serum or serum-free condition for 12 h in the absence or presence of XNJ. Luciferase activity was determined in cell lysates and normalized to Renilla activity. Results are representative of three independent experiments in duplicate

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