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Table 6 Anti-inflammatory activity of 80 % methanol extract of the rhizomes of Rumex abyssinicus on carrageenan-induced mice paw edema following oral administration

From: Evaluation of wound healing and anti-inflammatory activity of the rhizomes of Rumex abyssinicus J. (Polygonaceae) in mice

Group

Mean change in the paw volume (ml)

Basal

1 h

2 h

3 h

4 h

Control

0.50 ± 0.04

0.61 ± 0.02

0.7 ± 0.03

0.69 ± 0.04

0.65 ± 0.03

Extract (250 mg/kg)

0.50 ± 0.02

0.60 ± 0.03 (1.64 %)

0.58 ± 0.04 (17 %)

0.55 ± 0.02a1 (20.29 %)

0.51 ± 0.02a2 (21.54 %)

Extract (500 mg/kg)

0.50 ± 0.03

0.55 ± 0.02 (9.84 %)

0.47 ± 0.04a3 (32.86 %)

0.44 ± 0.02a3 (36.23 %)

0.30 ± 0.03a3c3 (53.85 %)

Extract (750 mg/kg)

0.51 ± 0.01

0.48 ± 0.04 (21.31 %)

0.43 ± 0.02a3,c1 (38.57 %)

0.40 ± 0.04a3,c2 (42.03 %)

0.25 ± 0.02a3c3 (61.54 %)

Indomethacin (10 mg/kg)

0.53 ± 0.03

0.48 ± 0.03 (24.6 %)

0.35 ± .02a3c3 (50 %)

0.24 ± 0.02a3c3 (65 %)

0.10 ± 0.02a3c3 (84.6 %)

  1. n = 6 animals in each group; Values are expressed as mean ± SEM, with inhibition deppicted in parenthesis; data were analyzed by one way ANOVA followed by tuckey post hoc test;; aagainst control, cagainst 250 mg/kg; 1p < 0.05, 2p < 0.01, 3p < 0.001