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Table 1 Values of ED50, Emax and slope (S) of log dose–response curves of cromakalim in the presence and absence of antagonists, such as butylidenephthalide (Bdph), 4-aminopyridine (4-AP) and glibenclamide (GBC) in conscious normotensive rats

From: Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats

Response Antagonists ED50 (mg/kg) Emax S n
Change in systolic pressure (mmHg) Bdph (30 mg/kg, i.p.) 0.25 ± 0.01a −45 ± 5 −0.86 ± 0.04a 8
Vehicle (1 ml/kg, i.p.) 0.11 ± 0.00 −43 ± 6 −2.16 ± 0.29 8
4-AP (0.4 mg/kg, i.p.) 0.18 ± 0.00a −30 ± 4 −0.82 ± 0.08a 6
Vehicle (1 ml/kg, i.p.) 0.10 ± 0.00 −34 ± 3 −1.83 ± 0.06 6
GBC (10 mg/kg, i.v.) 0.52 ± 0.01a −53 ± 6 −1.08 ± 0.20 6
Vehicle (1 ml/kg, i.v.) 0.23 ± 0.01 −47 ± 4 −0.72 ± 0.15 6
  1. All values are shown as mean ± SEM, and n is the number of rats
  2. aSignificantly different from vehicle (P < 0.01)