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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats

Fig. 3

Time course of effects of cromakalim on systolic pressure in conscious normotensive rats, pretreated with butylidenephthalide (Bdph, a), 4-aminopyridine (4-AP, b), glibenclamide (GBC, c) or their vehicles (controls). After both second baseline values were determined, Bdph, 4-AP or GBC was immediately injected at 0 min. Thirty min after injection of Bdph, 4-AP or GBC, 0.1, 0.15, or 0.3 mg/kg of cromakalim was injected (i.v.), respectively. Each point represents mean ± SEM, and n is the number of rats. * P < 0.05, ** P < 0.01, *** P < 0.001 compared to their respective control

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