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Table 8 Analgesic activity of E. dracunculoides of hot plate test in rat

From: Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides

Treatment (mg/kg)

Latency time sec

Percent analgesia

0 h

30 min

60 min

90 min

30 min

60 min

90 min

DMSO (2 ml)

9.000 ± 0.894

9.833 ± 1.169

10.167 ± 0.752

10.167 ± 0.752

3.971 ± 3.588d

5.490 ± 3.378e

5.490 ± 3.378e

Morphine (10)

9.333 ± 1.032

21.000 ± 1.549

25.667 ± 1.032

22.500 ± 1.048

56.160 ± 9.114b

78.889 ± 5.853a

63.632 ± 5.449ab

EDH (300)

9.833 ± 1.169

21.667 ± 1.633

24.833 ± 1.169

24.000 ± 1.095

58.304 ± 9.974a

74.309 ± 5.864b

70.206 ± 5.445a

EDA (300)

9.666 ± 0.816

14.167 ± 1.602

15.167 ± 1.169

16.833 ± 0.752

22.164 ± 6.680c

26.964 ± 6.193d

35.223 ± 3.210d

EDE (300)

10.000 ± 0.894

16.000 ± 1.414

22.333 ± 1.211

21.333 ± 1.032

29.804 ± 8.470bc

61.811 ± 4.528b

56.508 ± 6.363bc

EDEW (300)

9.666 ± 0.816

15.500 ± 1.048

19.333 ± 1.633

19.667 ± 1.032

28.676 ± 4.528bc

47.331 ± 9.410c

49.204 ± 4.254c

EDM (300)

9.666 ± 0.816

17.833 ± 1.472

20.000 ± 1.788

19.500 ± 1.048

40.196 ± 6.553b

50.959 ± 7.486bc

48.248 ± 5.943c

  1. EDH E. dracunculoides n-hexane extract, EDA E. dracunculoides aqueous extract, EDE E. dracunculoides ethyl acetate, EDEW E. dracunculoides ethyl acetate + water extract, EDM E. dracunculoides methanol extract
  2. Data values shown represent mean ± SD (n = 6). Means with different superscript (a-e) letters in the column are significantly (P < 0.05) different from one another