Quantitative structure-activity relationship of molecules constituent of different essential oils with antimycobacterial activity against Mycobacterium tuberculosis and Mycobacterium bovis

Table 1 Antimycobacterial activity of terpenes and phenylpropanes against M. tuberculosis and M. bovis

Compounds		Antimycobacterial activity (μg/mL)
		M. tuberculosis	M. bovis
		MIC	MIC
1	Cinnamic Acid	8.16 ± 3.32^FG	7.29 ± 4.73^DE
2	Camphor	41.66 ± 14.43^CD	50.00 ± 0.00^B
3	p-Anisaldehyde	4.16 ± 1.81^FG	10.41 ± 3.61^DE
4	β-pinene	10.41 ± 3.61^CDE	41.66 ± 14.43^CDE
5	3-Carene	16.66 ± 7.22^CDEF	33.33 ± 14.43^CDE
6	p-Cymene	91.66 ± 14.43 ^A	91.66 ± 14.43 ^A
7	β-Caryophyllene	100.00 ± 0.00 ^A	100.00 ± 0.00 ^A
8	Carvacrol	2.02 ± 0.88^FG	5.20 ± 1.81^DE
9	(+) Carvone	20.83 ± 7.22^CDE	41.33 ± 15.01^BCDE
10	Cinnamaldehyde	3.12 ± 0.00^EFG	12.50 ± 0.00^DE
11	β-Citronellol	6.25 ± 0.00^FG	10.41 ± 3.61^DE
12	Cuminaldehyde	10.41 ± 3.61^DEFG	20.83 ± 7.22^CDE
13	Estragole	20.83 ± 7.22^DEFG	25.00 ± 0.00^BCDE
14	Eucalyptol	41.66 ± 14.43^CDE	41.66 ± 14.43^B
15	Eugenol	25.00 ± 0.00^DEFG	20.83 ± 7.22^BCD
16	Geraniol	12.50 ± 0.00^EFG	12.50 ± 0.00 ^CDE
17	(+) Limonene	25.00 ± 0.00^CDE	41.66 ± 14.43^BCD
18	Linalool	33.33 ± 14.43^CDE	41.66 ± 14.43^BC
19	Menthol	41.66 ± 14.43 ^AB	83.33 ± 14.43^B
20	Myrcene	25.00 ± 0.00^CDEF	33.33 ± 14.43^BCD
21	Sabinene	33.33 ± 14.43^DEFG	25.00 ± 0.00^BC
22	t-Anethole	20.83 ± 7.22^BC	58.33 ± 14.43^BCDE
23	α-Terpinene	10.41 ± 3.61^DEFG	20.83 ± 7.22^CDE
24	Terpinolene	8.33 ± 3.61^CDEF	33.33 ± 14.43^DE
25	Thymol	0.78 ± 0.01^G	2.02 ± 0.88^E
TX	Isoniazid	0.26 ± 0.01^G	0.16 ± 0.3^E
TX	Rifampicin	0.60 ± 0.14^G	0.50 ± 0.01^E

Values are the average and standard deviation of triplicate assays. Superscripts correspond to clusters by similarity analysis done by Tukey mean analysis

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