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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity

Fig. 4

Effect of harpagoside on iNOS gene expression and NO synthesis of microglial cells. Three hours’ hypoxia stimulates microglial cells iNOS gene expression; with its maximal effect occurred at 6 h’ culture; the pre-incubation of harpagoside can down-regulate hypoxia-induced iNOS gene expression. Besides, we found that when microglial cells cultured under hypoxia condition (1 % O2), active synthesis of NO was observed; while 1 h pre-incubation with harpagoside on microglial cells does reduce the NO production by microglial cells under hypoxic condition (n = 4). Note: *: p < 0.05

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